Airborne laser scanning (ALS) is a widely used technique for the sampling of the earth’s surface. Nowadays a wide range of ALS sensor systems with different technical specifications can be found. One parameter is the laser wavelength which leads to a sensitivity for the wavelength dependent backscatter characteristic of sensed surfaces. Current ALS sensors usually record next to the geometric information additional information on the recorded signal strength of each echo. In order to utilize this information for the study of the backscatter characteristic of the sensed surface, radiometric calibration is essential. This paper focuses on the radiometric calibration of multi-wavelength ALS data and is based on previous work on the topic of radiometric calibration of monochromatic (single-wavelength) ALS data. After a short introduction the theory and whole workflow for calibrating ALS data radiometrically based on in-situ reference surfaces is presented. Furthermore, it is demonstrated that this approach for the monochromatic calibration can be used for each channel of multi-wavelength ALS data. The resulting active multi-channel radiometric image does not have any shadows and from a geometric viewpoint the position of the objects on top of the terrain surface is not altered (the result is a multi-channel true orthophoto). Within this paper the approach is demonstrated by three different single-wavelength ALS data acquisition campaigns (532nm, 1064nm and 1550nm) covering the area of the city Horn (Austria). The results and practical issues are discussed.